Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis
Summary: The transitions from developing to adult quiescent and activated neural stem cells (NSCs) are not well understood.Here, we use single-cell transcriptional profiling and lineage tracing to characterize these transitions in the murine forebrain.We show that the two forebrain NSC parental populations, embryonic cortex and ganglionic eminence